PRODUCT IDENTIFICATION

H.S. CODE

2915.90.0090

TOXICITY

SMILES

C(CCC)(CCC)C(O)=O

CLASSIFICATION

Anticonvulsant; Antiepileptic; Antimanic agent; Central Nervous System Depressant; Enzyme inhibitor; GABA agent; Neurotransmitter Agent; Psychotropic Drug; Tranquilizing Agent;

PHYSICAL AND CHEMICAL PROPERTIES

SOLVENT SOLUBILITY

4.97

AUTOIGNITION

NFPA RATINGS

REFRACTIVE INDEX

111 C

GENERAL DESCRIPTION & EXTERNAL LINKS

Valproic acid and its derivatives are used solely or in combination with other anticonvulsants to prevent seizures and migraines. Valproates are effective against the manic phase of bipolar disorder. A fatty acid with anticonvulsant properties used in the treatment of epilepsy. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of voltage dependent sodium channels.

Wikipedia Linking:http://en.wikipedia.org/wiki/Valproic_acid

http://www.merck.com/
Special Alerts-Valproic Acid and Derivatives: Risk of Birth Defects - December 2009
The U.S. Food and Drug Administration (FDA) has issued a reminder to healthcare professionals and patients about the increased risk of neural tube defects (1 in 20 babies born exposed to valproic acid and derivatives compared to ~1 in 1500 not exposed), as well as, other major birth defects (eg, craniofacial defects, cardiovascular malformation), especially with exposure during the first 12 weeks of pregnancy. Information from the North American Antiepileptic Drug Pregnancy Registry notes a fourfold increase in congenital malformations with exposure to valproic acid monotherapy during the 1st trimester of pregnancy when compared to monotherapy with other antiepileptic drugs (AED)..........

http://www.sleepassociation.org/
Aggressive agitation, agitation and insomnia with generalized anxiety are commonly observed in Alzheimer's disease. These symptoms remain a principal problem in the clinical management of elderly patients. Neuroleptics are commonly the selected medication for controlling severe aggression, especially the violent out bursts often seen in demented patients. Their use is frequently complicated by side effects, particularly somnolence and confusion. Valpromide and Carbamazepine have been efficacy alternatives and very well tolerated. We report eight cases of demented patients who presented an agitation and aggressive behaviors and had been treated with Valpromide or Carbamazepine. The patients agitation was well controlled at that point and had no apparent side effects. A combination Valpromide or Carbamazepine with neuroleptics permitted a reduction doses of neuroleptics and their side effects. We think that these behaviors disorders belong to the mood disorders. The symptomatology is modified because an alteration of cognitive faculty.

APPEARANCE

ASSAY

98.0-102.0% (dry basis)

IMPURITY

0.1% max (Individual), 0.3% max (Total)

HEAVY METALS

20ppm max

WATER

1.0% max

RESIDUE ON IGNITION

0.1% max

20 KG per bucket